PRODUCT FOR THE REGENERATION OF CARTILAGE
International application PCT/RU2017/000521, priority 14.07.2016
Patent applications for inventions
- Eurasia No. 201600575 stated 14.07.2016
- Europe No. 3484928 stated 11.02.2019
- China No. 20178043652 stated 14.01.2019
- USA No. 2019002580 stated 08.01.2019
- Korea No. 20197004225 stated 13.02.2019
- India No. 201917003657 stated 30.01.2019
- Israel No.26417419 stated 09.01.2019
A number of protein and DNA molecules have been developed that allow for significant regeneration ofdamaged cartilage tissue, and which are targeted and easy to use, as well as safe and economical inproduction and use.
The advantage of using the developedfusionprotein is expressed in the regeneration of cartilage bytargeting thefusionprotein to the cartilage matrix, as well as stimulating the growth of the requiredcells through the use of a growth factor in the design ofthefusionprotein. A modification of thisfusionprotein for oral delivery has also been developed. In this case, the protein additionally contains an Fcantibody fragment, or a polypeptide binding to FcRn, and / or transferrin, or a fragment thereof. Thecomponents of thefusionprotein are connected by flexible bridges, which allows to achieve thefunctioning of each component of the protein and effectively restore cartilage.
The above proteins or plasmid DNA encoding suchfusionproteinscan be components of the proposedpreparation for cartilage regeneration.
The result of the use of afusionprotein or a drug based on it according to the invention (variants) isexpressed in an increase in the effectiveness of the treatment of cartilage damage, sincethefusionprotein works only in cartilage tissue. This is achieved by exposing thefusionprotein exclusively tocartilage,usinga ligand to the matriline. Thus, the tool accumulates in the target tissue–is present inahigh concentration, unlike the drug just circulating in the bloodstream.
The result of the use of a hybrid protein or a drug based on it according to the invention (variants) isexpressed in the regeneration of cartilage by targeting thefusionprotein to the cartilage matrix, as wellasattracting and stimulating the growth of the required cells, thanks to the use of a growth factor in theconstruction of a fusion protein.