Разработана вакцина против covid-19

SCIENTIFIC ARTICLES

Articles in Russian journals

  1. Enhancement of immunogenicity of plasmid DNA expressing gag protein of human immunodeficiency virus during co-transfection by plasmid carrying defensin-2β gene / Vorozhtsova E. V., Dukhovlinov I. V., Klimov N. A., Kozlov A. P. // Vestnik of St. Petersburg University. Series 3, Biology. — 2010. — No. 4. S. pages 108 – 116.
  2. The preparation of recombinant P17 protein of subtype A human immunodeficiency virus / Al-shekhadat R. I., Dukhovlinov I. V., Kubatov A. I. et al. / / Biotechnology. — 2010. — No. 6. — P. 19-26.
  3. Regenerative non-viral gene therapy of the skin damages of mammals / Efremov A. M., Dukhovlinov I. V., Dizhe E. B. et al. / / Cytology. — 2010.  Vol.52, — No. 5. — P. 371. 
  4. The study of the pharmacokinetics of three dosage forms of the drug for regenerative gene therapy of interfacial tissues damage of different etiology / Dukhovlinov I. V., Al-Shekhadat R. I., Orlov A. I. // Pharmacokinetics and pharmacodynamics. – 2013. – Vol.1. No. 6. — P. 35 – 39.
  5. Evaluation of tissue regeneration using a gene therapy product containing PCIGF plasmid, on experimental models of wounds of various origins / Dukhovlinov I. V., Al-Shekhadat R. I., Fedorova E. A., et al. / / Vestnik of Saint Petersburg University. Series 11, Medicine. – 2013. – No. 3. — P. 178 – 191.
  6. Optimization of dosage forms of the drug for regenerative gene therapy of interfacial tissues damage of different etiology / Dukhovlinov I. V., Al-Shekhadat R. I., Fedorova E. A., et al. / / Vestnik of Saint Petersburg University. Series 11, Medicine. – 2013. – No. 4. — P. 145 – 150.  
  7. Creation of fusion recombinant proteins based on VP6 and VP8 proteins of human rotavirus of group A / Dukhovlinov I. V., Bogomolova E. G., Fedorova E. A., Simbirtsev A. S.  // Infection and immunity. – 2014. – Vol. 4, No. 3. — P. 229 – 234. 
  8. Obtaining of recombinant CRM197 in E. coli cells / Dukhovlinov I. V., Bogomolova E. G., Fedorova E. A. et al. // Infection and Immunity. – 2015. – Vol. 5, No. 1. – P. 37 – 44.
  9. Study of immunogenicity of fusion recombinant proteins based on VP6 and VP8 of human group A rotavirus / I. V. Dukhovlinov, E. G. Bogomolova, E. A. Fedorova, A. S. Simbirtsev // Epidemiology and vaccine prophylaxis. — 2015. — Vol. 14, No. 2 (81). — P. 96 – 101. 
  10. Preparation of recombinant protein TB10. 4 of Mycobacterium tuberculosis in Escherichia coli cells / I. V. Dukhovlinov, E. A. Fedorova, O. A. Dobrovolskaya // Infection and Immunity. – 2015. – Vol. 5, No. 4. – P. 315 – 322.
  11. Protective ability of candidate vaccine containing recombinant TB10. 4 protein in the expression system of E. coli cells in experimental tuberculosis / T. I. Vinogradova, E. A. Fedorova, I. V. Dukhovlinov et al. / / Medical immunology. — 2015. – Vol. 17, No. 5. — P. 196. 
  12. Antorex causes an increase in intracellular concentration of Ca2+ in macrophages. / L. S. Milenina, Z. I. Krutetskaya, I. V. Dukhovlinov, et al. / / International scientific Institute “Educatio”. Monthly scientific journal. – 2015. — No. 11(18). Part 1 ed., – pp. 21-23.
  13. Creation of immunogen against human papilloma virus based on a fusion recombinant protein L2E7 / I. V. Dukhovlinov, I. S. Malakhov, A. S. Simbirtsev et al. / / Infection and Immunity. – 2016. – Vol. 6, No. 4. – P. 345 – 352.
  14. Development of a candidate substance of recombinant CRM197 protein / I. V. Dukhovlinov, O. A. Dobrovolskaya, E. A. Fedorova, et al. / / Epidemiology and vaccination. — 2016. — Vol. 15, No. 1 (86). — P. 93 — 98.
  15. The study of a protective activity of candidate vaccines against rotavirus based on FLICVP6VP8 recombinant protein / Dukhovlinov I. V., Simbirtsev A. S., E. A. Fedorova, et al. / / Medicinal Immunology. — 2016. – Vol. 18, No. 5.  Pp. 417-424.
  16. Fusion proteins based on immunogenic epitopes of surface factors of streptococcal pathogenicity as a vaccine for the prevention of infection caused by group b streptococci / V. Yu. Filimonova, I. V. Dukhovlinov, A. N. Suvorov, et al. / / Medical academic journal. — 2016. – Vol. 16, No. 3. — p. 82-89.
  17. The study of a protective activity of a candidate vaccine against rotavirus based on FLICVP6VP8 recombinant protein / I. V. Dukhovlinov, E. G. Bogomolova, E. A. Fedorova, et al. / / Medical academic journal. — 2016. – Vol. 16, No. 4. — P. 147-148.
  18. Development of a drug based on a peptide antagonist to the orexin receptor / I. V. Dukhovlinov, N. A. Klimov, E. A. Fedorova, et al. / / Medical academic journal. – 2017. – Vol. 17, No. 2. – P. 42-47.
  19. Production of insulin-like growth factor 1 (IGF-1) encoded by plasmid DNA in vivo / I. V. Dukhovlinov, E. G. Bogomolova, E. A. Fedorova, et al. / / Medical academic journal. – 2017. – Vol. 17, No. 3. – p. 47 – 52.
  20. Obtaining of a fusion recombinant FLU-CHIM protein containing the main epitopes of influenza A and B viruses / I. V. Dukhovlinov, O. A. Dobrovolskaya, A. I. Orlov // Infection and immunity. -2017. – Vol. 7(2). – P. 117-122.
  21. Study of antigenic activity of experimental samples of conjugated vaccines based on synthetic oligosaccharide ligands and CRM197 carrier protein / I. V. Dukhovlinov, E. G. Bogomolova, E. A. Fedorova, et al. / / Medical immunology. — 2017. – Vol. 19, No. 2. — P. 157-164.
  22. Research of protective properties of vaccine preparation based on Ag85, TB10 and FliC recombinant proteins [Text] / V. V. Eremeev, I. V. Dukhovlinov, E. A. Fedorova, et al. / / Medical immunology. – 2017. – Vol. 19. – No. 2, pp. 197-202.
  23. Experimental evaluation of the anti-radiation effectiveness of recombinant flagellin / / Murzina E. V., Sofronov G. A., Dukhovlinov I. V. et al. / / Bulletin of the Russian military medical Academy. — 2017.  No. 3 (59).  P. 122-128.
  24. Study of duration of immune response induced by a vaccine based on Ag85, TB10 and FliC recombinant proteins / Eremeev V. V., Dukhovlinov I. V., Fedorova E. A. et al. / / Medical immunology. – 2018. – Vol. 20, No. 2, Pp. 271-276.
  25. Study of production of nontoxic variant of diphtheria toxin in Escherichia coli cells / Dukhovlinov I. V., Bogomolova E. G., Fedorova E. A., et al. / / Medical academic journal. – 2018. – Vol. 18, No. 1. – P. 64 — 70.
  26. Development and preparation of the active component of the combined DNA vaccine against herpes viruses types I-VIII / Kolmakov N. N., Fedorova E. A., Dukhovlinov I. V. et al. / / Medical alphabet. — 2018. — T. 2.  No. 19 (356). — P. 9.
  27. Development of a monoclonal antibody specific to the epitope of P17 HIV-1 protein / Kolmakov N. N., Dukhovlinov I. V., Simbirtsev A. S. et al. / / Medical alphabet. — 2018. — T. 2.  No. 19 (356). – Pp. 12-13.
  28. Obtaining recombinant insulin-like growth factor-1 and its effect on neuroblastoma cells in vitro / Dukhovlinov I. V., Klimov N. A., Simbirtsev A. S. et al. / / Medical academic journal. — 2018. – Vol. 18.  No. 4. — P. 34-41.
  29. Pharmacokinetics of two forms of recombinant insulin-like growth factor 1 in the blood of mice / Dukhovlinov I. V., Evsyukov I. V., Kolmakov N. N. et al. / / Cytology. — 2019. — T. 61 (7). — P. 564.

Articles in foreign journals

  1. Evolutionary new sequences expressed in tumors / Kozlov A.P., Galachyants Y.P., Dukhovlinov I.V. et al. / Infectious Agents and Cancer. — 2006. — Vol. 1. № 1. — P. 8.
  2. Nonviral regenerative gene therapy of mammalian cutaneous damages / Efremov A.M., Dukhovlinov I.V., Dizhe E.B. et al. / Cell and Tissue Biology. 2010. — Vol. 4. № 4. — P. 362-371.
  3. Obtaining of the p17 recombinant protein of human immunodeficiency subtype A virus / Al-Shekhadat R.I., Dukhovlinov I.V., Kobatov A.I. et al. / Applied Biochemistry and Microbiology. — 2011. — Vol. 47. — № 8. — P. 730-736.
  4. Study of immunogenicity of recombinant proteins based on hemagglutinin and neuraminidase conservative epitopes of influenza A virus / I. Dukhovlinov, R. Al-Shekhadat, E.A. Fedorova et al. /Med Sci Monit Basic Res. – 2013. – Vol. 19. – P. 221 – 7.
  5. Chimeric Protein PSPF, a Potential Vaccine for Prevention Streptococcus pneumoniae Infection / A. Suvorov, I. Dukhovlinov, E. Fedorova et al. / J Vaccines Vaccin. – 2015. – Vol. 6. – P. 304.
  6. Study of Antigenic Activity of Experimental Samples of the Conjugated Vaccines Based on Synthetic Oligosaccharide Ligands and CRM197 Carrier Protein against Candida albicans, Aspergillus fumigatus and Pseudomonas aeruginosa / E.G. Bogomolova, I.V. Dukhovlinov, E.A. Fedorova et al. / Key Engineering Materials. – 2017. — Vol. 743. -P. 349-354.

Conference proceedings

  1. O. A. Dobrovolskaya / Obtaining Tb10. 4 Mycobacterium tuberculosis recombinant protein in Escherichia coli cells [Text] / O. A. Dobrovolskaya, E. A. Fedorova, E. K. Chernyaeva, I. V. Dukhovlinov, A. S. Simbirtsev / / Biology-science of the XXI century: 18th international pushchinskaya school-conference of young scientists: Sat. / Pushchino, 2014. – P. 64-65. 
  2. Bogomolova, E. G. Creation of hybrid recombinant proteins based on VP6 and VP8 proteins of human rotavirus group a and study of their antigenic properties / E. G. Bogomolova, I. V. Dukhovlinov, E. A. Fedorova, A. S. Simbirtsev // I international conference of young scientists: biotechnologists, M431 molecular biologists and virologists : Sat.  / Novosibirsk. state University of the so — Novosibirsk, 2014. – P. 16. 
  3. Dobrovolskaya, O. A. production of TB10.4 Mycobacterium tuberculosis recombinant protein in the cells of E. coli strain / O. A. Dobrovol’skaya, E. A. Fedorova, E. K., Chernyaeva, I.V. Dukhovlinov, A. S. Simbirtsev // I international conference of young scientists of biotechnology, М431 molecular biologists and virologists : Sat. proc. / Novosibirsk. state University — Novosibirsk, 2014. – P. 18.
  4. Dobrovolskaya, O. A. Obtaining recombinant TB10. 4 protein of Mycobacterium tuberculosis in Esherichia coli cells / O. A. Dobrovolskaya, E. A. Fedorova, E. K. Chernyaeva, I. V. Dukhovlinov, A. S. Simbirtsev // GMO: history, achievements, social and environmental risks : Abstracts of the international conference / St. Petersburg, 2014. – P. 36.
  5. Dukhovlinov I. V., The preparation of recombinant CRM197 in E. coli cells / I. V. Duhovlinov, E. A. Fedorova, E. G. Bogomolova, O. Dobrovolskaya, E. N. Chernyaeva, R. I. Al-Shekhadat, A. S. Simbirtsev // GMOs: history, achievements, social and environmental risks : Abstracts of the international conference/ St.-Petersburg, 2014. – P. 42.
  6. Bogomolova, E. G. Study of immunogenicity of hybrid recombinant proteins based on VP6 and VP8 proteins of human group A rotavirus / E. G. Bogomolova, I. V. Dukhovlinov, E. A. Fedorova, A. S. Simbirtsev // GMO: history, achievements, social and environmental risks : Abstracts of the international conference / St. Petersburg, 2014. – P. 45.
  7. Vitovskaya, M. L. Protective ability of the candidate vaccine containing TB10.4 recombinant protein in the expression system of E. coli cells in experimental tuberculosis / M. L. Vitovskaya, T. I.  Vinogradova, N. In. Zabolotnykh, O. Dobrovolskaya, E. A. Fedorova, E. K., Chernyaeva, I.V. Dukhovlinov, A. S. Simbirtsev // Pathogenesis, diagnostics and treatment of immunopathologic conditions. Immunology of tuberculosis: proceedings of the conference / Vol. 17, No. 3s. – St. Petersburg, 2015. – P. 132. 
  8. Vitovskaya, M. L. / Protective ability of a candidate vaccine containing recombinant TB10. 4 protein in the expression system of E. coli cells in experimental tuberculosis [Text] / M. L. Vitovskaya, T. I. Vinogradova, N. V. Zabolotnykh, O. A. Dobrovolskaya, E. A. Fedorova, E. K. Chernyaeva, I. V. Dukhovlinov, A. S. Simbirtsev // HIV-associated tuberculosis: epidemiological, clinical and social aspects. Mate. intl. scientific. scient. Conf. “HIV-associated tuberculosis: epidemiological, clinical and social aspects / Republican scientific and practical center of pulmonology and Phthisiology, Grodno state medical University, Belarusian respiratory society; ed. — Grenoble, 2015. — P. 85-86.
  9. Dobrovolskaya, O. A. Study of immunogenic and protective properties of a polyvalent recombinant vaccine against influenza A and B viruses / O. A. Dobrovolskaya, N. P. Mikhailova, A. I. Orlov, I. V. Dukhovlinov, L. A. Stepanova, L. M. Tsybalova, O. I. Kiselev // Actual directions of fundamental and applied research. Materials of VII international scientific-practical conference. n. – I. TS. “Academic”. 2015. – Pp. 11-13.
  10. Mirovskaya, A. A. Development of technology for isolation and purification of recombinant CRM197 for antitumor drug / A. A. Mirovskaya, E. G. Bogomolova, O. A. Dobrovolskaya, I. V. Dukhovlinov / / in the book: Traditions and innovations Proceedings of the scientific conference dedicated to the 187th anniversary of the St. Petersburg state technological Institute (technical University). — 2015. — P. 211.
  11. Development of technology for obtaining pharmaceutically acceptable CRM197 recombinant protein / Mirovskaya A. A. I., Dukhovlinov I. V., Bogomolova E. G., Dobrovolskaya O. A. / / Collection of abstracts of the VI Scientific and technical conference of students, postgraduates and young scientists (with international participation) “Week of science-2016” St. Petersburg state technological Institute (technical University). — 2016. — P. 270.
  12. Ishchuk, S. A. Expression of insulin-like growth factor 1 gene by plasmid dna electroporation in mice / S. A. Ishchuk, A. O. Akhmetshina, E. G. Bogomolova, I. S. Malakhov // VII international youth medical Congress “St. Petersburg scientific readings-2017” / Resp. ed. – SPb., 2017. — P. 177
  13. Malakhov, I. C. Creation of LE vaccine multiepitope recombinant protein against oncogenic HPV strains / I. S. Malakhov, S. A. Ischuk, A. Akhmetshina, A. A. Lukovenko // VII international youth medical Congress “St. Petersburg scientific readings-2017” / Ed. ed. – SPb., 2017. — P. 178-179. 
  14. Development of a candidate vaccine against rotavirus infection and study of efficacy on laboratory models / Bogomolova E. G., Dobrovolskaya O. A., Fedorova E. A., Dukhovlinov I. V., Simbirtsev A. S. / / Biotechnology: state and prospects of development Materials of the international forum. — 2018. — P. 168-169.
  15. Development of a monoclonal antibody specific to HIV-1 protein P17 / Dobrovolskaya O. A., Bogomolova E. G., Fedorova E. A., Dukhovlinov I. V., Kolmakov N. N., Lukovenko A. A. / / Biotechnology: state and prospects Materials of the international forum. — 2018. — P. 172-173.
  16. The new Benzotren drug synthesized on the basis of creatine impact on emotional and exploratory behavior of rats / Kashirin A. A., I. V. Duhovlinov, Pshenichnaya A. G., Lebedev A. A., Shabanov P. D. // Materials of all-Russian scientific conference of young scientists, dedicated to the 95th anniversary from birthday of A. A. Nikulin Professor, “Advances in modern pharmacological science” ed. by E. N. Yakusheva. — 2018. — PP. 57-58.