Development | Development of anti-age drugs
Development of anti-age drugs aimed at DNA repair
Therapeutic intervention in the fundamental causes of aging.
The development of drugs aimed at DNA repair is one of the most promising and rapidly developing areas in the field of geroprotectology – slowing down of aging. Accumulation of DNA damage over time is one of the main causes of aging at the molecular level. The rate of accumulation of somatic mutations correlates with life expectancy, and accelerated aging is directly related to defects in repair genes.
Normally, the body has an extensive system of repair pathways, however, with age, their efficiency decreases steadily.
Our strategy is to modulate these pathways to activate the cells' reparative potential. In this way, we slow down the accumulation of errors and actively restore genomic stability to halt cellular aging and increase healthy lifespan.
AOur developments:
1. Modulators of repair enzymes
Low-molecular-weight compounds that enhance the natural mechanisms of cell repair. These include activators of repair enzymes and inhibitors of the mTOR protein. Reducing the activity of this protein slows down cellular aging and reduces oxidative stress.
2. Biological polymers and recombinant proteins
These macromolecules (DNA or proteins) perform signaling and metabolic functions, directing the cells to actively restore their own genetic material.
3. Gene therapy constructs and genome editing
High-tech drugs that target long-term changes.
Development of anti-age drugs aimed at DNA repair
Therapeutic intervention in the fundamental causes of aging.
The development of drugs aimed at DNA repair is one of the most promising and rapidly developing areas in the field of geroprotectology – slowing down of aging. Accumulation of DNA damage over time is one of the main causes of aging at the molecular level. The rate of accumulation of somatic mutations correlates with life expectancy, and accelerated aging is directly related to defects in repair genes.
Normally, the body has an extensive system of repair pathways, however, with age, their efficiency decreases steadily.
Our strategy is to modulate these pathways to activate the cells' reparative potential. In this way, we slow down the accumulation of errors and actively restore genomic stability to halt cellular aging and increase healthy lifespan.
AOur developments:
1. Modulators of repair enzymes
Low-molecular-weight compounds that enhance the natural mechanisms of cell repair. These include activators of repair enzymes and inhibitors of the mTOR protein. Reducing the activity of this protein slows down cellular aging and reduces oxidative stress.
2. Biological polymers and recombinant proteins
These macromolecules (DNA or proteins) perform signaling and metabolic functions, directing the cells to actively restore their own genetic material.
3. Gene therapy constructs and genome editing
High-tech drugs that target long-term changes.
- Delivery of additional copies of genes encoding repair enzymes to cells.
- Use of genome editing systems (CRISPR/Cas). Correction of mutations in mitochondrial or nuclear DNA, as well as epigenetic reprogramming of cells for the purpose of rejuvenation.
Email:
