Recombinant proteins | Insulin-like Growth Factor
Insulin-like Growth Factor
IGF-1 (Insulin-like Growth Factor-1) is a protein belonging to the family of insulin-like growth factors that shares structural and functional similarities with insulin.
Functions of IGF-1:

• Circulates in the bloodstream while bound to carrier proteins
• Acts on cells through specific receptors
• Participates in endocrine, autocrine, and paracrine regulation of cell growth, development, and differentiation processes

Our developed IGF-1 is a human recombinant protein produced through genetic engineering using Escherichia coli cells. The human IGF-1 gene has been integrated into the bacterial genome, resulting in a peptide sequence with biological activity and pharmacological properties identical to naturally occurring IGF-1.
AMetabolic, Growth, and Regenerative Effects of IGF-1:

— Metabolic Effects
Stimulates glucose, fatty acid, and amino acid uptake while promoting accelerated fat loss without muscle catabolism

IGF-1 plays a pivotal role in muscle hypertrophy through:

• Satellite cell activation (increasing myonuclei number)
• Enhanced protein synthesis
• Myostatin suppression (inhibiting this growth-limiting protein)
• Increased amino acid uptake by muscle cells

— Reduces oxidative stress and inflammation

— Restores immune system function

— Accelerates tissue regeneration by:

• Increasing cellular mass in cartilage and muscle tissue
• Promoting repair of joints, ligaments, and skin lesions/burns
• Improving skin density and hair follicle nutrition

IGF-1 accelerates tissue regeneration by activating stem cell division at injury sites and boosting collagen production essential for tissue strength and elasticity. These processes enhance the healing of muscle microtears and ligament damage. Furthermore, IGF-1 reduces levels of pro-inflammatory cytokines, thereby decreasing inflammation and promoting faster recovery.

IGF-1 is critically important for musculoskeletal health as it actively stimulates osteoblasts to increase bone mineral density and prevent stress fractures. It accelerates cartilage tissue regeneration, which is particularly valuable for osteoarthritis and high-impact physical activities. Additionally, IGF-1 strengthens joint ligaments through enhanced collagen synthesis and serves as a powerful stimulant for muscle growth by promoting significant increases in muscle mass.

— Anti-Aging Effects
IGF-1 slows down key aging processes through its geroprotective action.

— Neuroprotective and Cognitive Benefits
IGF-1 demonstrates multiple neurological benefits by restoring nervous tissue function and supporting axonal growth and myelination. It provides neuroprotective effects while enhancing cognitive function in neurodegenerative diseases. The protein promotes recovery from ischemic damage and is used in therapeutic applications for stroke rehabilitation, nervous system injuries, and myocardial infarction treatment. Additionally, IGF-1 exhibits nootropic properties that support cognitive performance.

— Reproductive System Effects
In Men:
IGF-1 significantly enhances male fertility by stimulating Sertoli cell proliferation, increasing testicular volume, and improving spermatogenesis. It is clinically used to treat infertility conditions including oligoasthenospermia and asthenozoospermia.
The protein improves sperm functionality by:

• Enhancing motility and maturation
• Strengthening sperm membrane integrity through reduced intracellular calcium levels
• Boosting mitochondrial membrane potential for improved energy stability

Furthermore, IGF-1 positively influences sexual activity.

In Women:
IGF-1 supports female reproductive health by:

• Promoting follicle and oocyte development
• Treating intrauterine growth retardation
• Restoring proper placental function