Development| Recombinant proteins | Radioprotector

Radioprotector
Radioprotectors are substances that protect cells and tissues from damage caused by ionizing radiation. They are used to mitigate the negative effects of radiation both in medical applications (e.g., radiation therapy) and in high-radiation environments (e.g., nuclear industry workers or astronauts).

Mechanisms of action of radioprotectors:
Free radical scavenging
Radioprotectors neutralize free radicals generated by radiation, preventing damage to DNA, proteins, and lipids.

Antioxidant system activation
Some radioprotectors enhance production of natural antioxidants (e.g., glutathione) that protect cells from oxidative stress.

DNA repair stimulation
Radioprotectors can activate enzymes involved in DNA repair.

Alpha-adrenergic agonists
Stimulate alpha-adrenergic receptors in various tissues and organs. Cause vasoconstriction and reduce free radical formation - the primary source of radiation-induced cell damage.

Cell membrane protection
Certain compounds stabilize cell membranes, preventing radiation-induced damage.
ARadiomitigators
Radiomitigators are substances administered after radiation exposure to reduce damage and accelerate recovery.

Mechanisms of action
DNA repair stimulation
Activates enzymes involved in repairing damaged DNA.

Inflammation reduction
Suppresses radiation-induced inflammatory processes.

Tissue regeneration stimulation
Accelerates recovery of damaged tissues.

We have developed a long-acting radioprotective drug based on a genetically engineered polypeptide, possessing radiomitigating properties and DNA repair capabilities. It activates the body's natural systems, initiating anti-inflammatory, regenerative, and reparative processes, while also stimulating innate nonspecific immunity by enhancing expression of cell repair genes.

Confirmed efficacy
Demonstrated effectiveness in small animal models at lethal radiation doses (8.0 Gy). The developed drug ensured 86.7% survival rate. It also promoted hematopoietic recovery post-irradiation and maintained safe levels of proinflammatory cytokines.

Advantages

• Non-toxic
• Suitable for course administration
• Promotes body recovery processes
• Applicable for adaptogenic prevention
• Effective for treating radiation reactions and complications
• Long-lasting action

The systemic effect accelerates recovery of radiation-sensitive tissues by activating proinflammatory signaling pathways and enhancing secretion of hematopoietic growth factors.

• Novel and unique drug production technology
• Prevents and reduces severity of radiation syndrome manifestations and its delayed/long-term effects
• Broad-spectrum radioprotector effective against both acute and chronic radiation exposure, as well as combined radiation-chemical-biological exposures
• Can be used both before and after clinical manifestation
• Acts as a paracrine stimulator of reparative cell proliferation in various tissues
• Reduces risk of tumor transformation in organs and tissues

Due to its mechanism of action, the drug offers potential for repurposing and provides multifunctional effects.